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Structure of Cannabinol

Cannabinol (CBN) is a weak psychoactive cannabinoid found only in trace amounts in Cannabis sativa and Cannabis indica. It is mostly a metabolite of tetrahydrocannabinol (THC). CBN acts as a weak agonist of CB1 receptors but has a higher affinity to CB2 receptors, with lower affinities in comparison to THC. Because of its somewhat selective CB2 agonism, it is used experimentally as an immunosuppressant.[1]

Additional Resources


  1. Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors (1998), Link Hub